1,4-Dioxane hydrochloride → HCID 67503792, compound

Participants

Reaction Steps

tert-Butyl (1-{4-[2-(3-amino-4-methylphenyl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutyl)carbamate (28.2 mg, 0.0482 mmol) was dissolved in DCM (1 mL). 4M HCl/dioxane (1 mL) was added to the mixture and stirred at room temperature for 2 hours. The mixture was concentrated and solidified with ether. The precipitated solids were collected by filtration and washed with ether to afford desired product (30.2 mg, 99.3%) as pale yellow solid. 1HNMR (DMSO-d6) 400 MHz δ: 8.86-8.70 (m, 2H), 8.63 (s, 1H), 8.11 (dd, J=4.8, 1.4 Hz, 1H), 7.92 (dd, J=8.0, 1.8 Hz, 1H), 7.70-7.64 (m, 1H), 7.57-7.52 (m, 2H), 7.41-7.35 (m, 1H), 7.35-7.28 (m, 3H), 7.19-7.10 (m, 3H), 6.91 (dd, J=8.0, 1.4 Hz, 1H), 6.75 (dd, J=8.0, 4.8 Hz, 1H), 2.64-2.37 (m, 4H), 2.30 (s, 3H), 2.26-2.13 (m, 1H), 1.89-1.75 (m, 1H); LCMS: 485 [M+H].

Provenance & Evidence