1,4-Dioxane hydrochloride → HCID 69087688, compound

Participants

Reaction Steps

Methyl{4-[3-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-2-yl]phenyl}carbamate (41 mg, 0.050 mmol) in MeOH (0.5 mL) was added 4N HCl-dioxane (2 mL) and stirred at room temperature for 24 hours. The mixture was concentrated to afford the desired product (35 mg, 83%) as a yellow solid. 1HNMR (DMSO-d6) 400 MHz δ: 9.79 (s, 1H), 8.79-8.73 (m, 3H), 8.14 (dd, J=4.0 Hz and 1.7 Hz, 1H), 7.96 (dd, J=8.0 Hz and 1.1 Hz, 1H), 7.56 (d, J=8.0 Hz, 2H), 7.44-7.40 (m, 4H), 7.34-7.30 (m, 3H), 7.17 (t, J=7.2 Hz, 1H), 6.91 (dd, J=8.0 Hz and 1.1 Hz, 1H), 6.78 (dd, J=8.0 Hz and 4.6 Hz, 1H), 3.66 (s, 3H), 2.57 (t, J=7.7 Hz, 4H), 2.24-2.16 (m, 1H), 1.85-1.78 (m, 1H). LCMS: 529 [M+H].

Provenance & Evidence