Trifluoroacetic acid → HCID 16129174, compound

Participants

Reaction Steps

A solution of 4′-C-ethynyl-5′-O-(dimethoxytrityl)-3′-fluoro-3′-deoxythymidine (12, X═F) (1 mmol) in a solution of 1% trifluoroacetic acid in methylene chloride (20 mL) is stirred at room temperature for 3 h and neutralized with ammonium hydroxide. Solvent is evaporated to dryness under reduced pressure and the residue is purified by silica gel column chromatography (2-5% MeOH in methylene chloride) to give 4′-C-ethynyl-FLT (Ia, X═F).

Provenance & Evidence