Tetrabutylammonium Fluoride → HCID 86594456, compound

Participants

Reaction Steps

Then, 0.27 ml (0.274 mmol) of 1M TBAF solution in tetrahydrofuran was added dropwise to a solution which had been prepared by dissolving 73 mg (0.137 mmol) of [3-(2-amino-6-chloro-purine-9-yl)-5-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclopentyl]-methanol in 0.7 ml of tetrahydrofuran at room temperature, and the resulting mixture was stirred for 1.5 hrs. After completion of the reaction, the reaction mixture was condensed and the residue thus obtained was isolated by HPLC to obtain 34 mg of the title compound (yield: 84%).

Provenance & Evidence