Hydrochloric Acid → HCID 86665050, compound

Participants

Reaction Steps

To a solution of (S)-ethyl 6-bromo-1-(1-(tert-butoxycarbonyl)piperidin-3-yl)-4-oxo-1,4-dihydro-1,7-naphthyridine-3-carboxylate (Intermediate 54, 6.37 g, 13.26 mmol, 1 equiv.) in dichloromethane (53 mL) was added 4 N hydrogen chloride (13.26 mL, 53.04 mmol, 4 equiv.). This was stirred at room temperature for 8 h. The precipitate was washed with diethyl ether and dried to provide (S)-ethyl 6-bromo-4-oxo-1-(piperidin-3-yl)-1,4-dihydro-1,7-naphthyridine-3-carboxylate hydrochloride as a solid (4.67 g, >99%).

Provenance & Evidence