反应详情

温度

80 °C

In a 25 mL flask 5-bromo-2-(3-ethylureido)pyridine-4-carbothioamide (Intermediate 6, 478 mg, 1.58 mmol) and 2-bromo-1-(1-methyl-1H-pyrazol-4-yl)ethanone (Intermediate 96, 352 mg, 1.73 mmol) were suspended in ethanol (10 mL). The reaction mixture was heated at 80° C. for 12 h, cooled to room temperature and concentrated to one half the volume under reduced pressure. The resulting solids were filtered and washed with acetonitrile. Isolation gave 640 mg of the title compound as an off-white solid.

1. temperaturecooled to room temperature
2. concentrationconcentrated to one half the volume under reduced pressure
3. filtrationThe resulting solids were filtered
4. washwashed with acetonitrile