Formic Acid → HCID 178432647, compound

Participants

Reaction Conditions

Reaction Steps

5-Bromo-6-methylpicolin-imido-hydrazide (1 equiv) and formic acid (15 equiv) were combined and heated with stirring at 100° C. for 6 h. The reaction was cooled to room temperature and diluted with methanol. The resulting slurry was stirred for 30 min and then partially concentrated under reduced pressure to ˜20% of the total volume. The resulting mixture was again diluted with methanol and partially concentrated under reduced pressure to ˜20% of the total volume. The resulting solids were collected by filtration, washed three times with water and dried under reduced pressure to provide the desired product in 84% yield, as an off-white solid. MS (ESI) m/z 238.9 [M]+, 240.9 [M+2]+.

Provenance & Evidence