HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[3-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid → Ethyl 2-(1-{[3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[3-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid | HCID 2060883 | — |
| Reactant | HCID 178470098 | HCID 178470098 | — |
| Product | Ethyl 2-(1-{[3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate | HCID 58242731 | — |
Reaction Steps
4-[4-(Ethoxycarbonyl)-1,3-thiazol-2-yl]piperidinium chloride (VI-1, 5.50 g) is reacted analogously to Example IV-1 with [3-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid (3.86 g). This gives, after chromatographic purification, ethyl 2-(1-{[3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate (5.1 g, 62%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08569509B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-154611cf63514dc5824cd36dffa82d92 |
| Source note | uspto-grants-2013_10 |