HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Naphthol → HCID 44468506, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Naphthol | HCID 7005 | — |
| Reactant | 2-(1-{[3,5-Bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carboxylic acid | HCID 44469184 | — |
| Product | HCID 44468506 | HCID 44468506 | — |
Reaction Steps
2-(1-{[3,5-Bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carboxylic acid (III-1, 7.00 g) is reacted analogously to Example I-811 with 1-naphthol (3.12 g). This gives, after chromatographic purification, 1-naphthyl-2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate (4.0 g, 44%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08569509B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-183f27bbc42b478bb25a2256dc06af14 |
| Source note | uspto-grants-2013_10 |