2,6-Dimethoxybiphenyl → 2,4-Dimethoxy-3-phenylbenzaldehyde

HRID 1047340Notes

Reaction equation

HRID 1047340 reaction equation
[C:1]1([C:7]2[C:12]([O:13][CH3:14])=[CH:11][CH:10]=[CH:9][C:8]=2[O:15][CH3:16])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.ClC1C(OC)=C(C=CC=1OC)[CH:21]=[O:22]>>[CH3:16][O:15][C:8]1[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[C:12]([O:13][CH3:14])[CH:11]=[CH:10][C:9]=1[CH:21]=[O:22]

Participants

3

Reactant 2

HCID 9142572,6-DimethoxybiphenylHCID 133437053-Chloro-2,4-dimethoxybenzaldehyde

Product 1

HCID 219461432,4-Dimethoxy-3-phenylbenzaldehydeYield 95%

Procedure

Compound 2c was synthesized from 1c in 95% yield using the procedure described for 2a. 1H NMR(acetone-d6): δ 10.28 (s, 1H), 7.88 (d, J=8.8 Hz, 1H), 7.42-7.49 (m, 5H), 7.10 (d, J=8.8 Hz, 1H), 3.89 (s, 3H), 3.48 (s, 3H).

Sources & evidence

ORD record
ord-75b5c14695194be1999f87f24d1ebe50
Source dataset
uspto-grants-2013_10
Patent number
US08569516B2

Reaction notes

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