Ethanol → HCID 57967274, compound

Participants

Role	Name	HCID	Charge
Reactant	Ethanol	HCID 702	—
Reactant	2-(4-Fluorophenyl)acetyl isothiocyanate	HCID 23153248	—
Reactant	4-(2-(5-(1,3-Dioxan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluoroaniline	HCID 57967258	—
Solvent	Toluene	HCID 1140	—
Product	HCID 57967274	HCID 57967274	101%

Reaction Steps

To a solution of isothiocyanate 2 (13.17 g, 67.4 mmol) in a mixture of toluene (100 ml)/EtOH (100 ml) in a 500 mL round-bottom flask was added aniline 31 (23.8 g, 56.2 mmol). The mixture was stirred for 1 h at room temperature and concentrated. The solid was triturated with toluene (100 mL) for 1 h, collected by filtration, washed with toluene (20 ml). The solid was dried under vacuum for 2 h to give crude 32 (35.10 g) which was used in the next step without any further purification. MS (m/z): 619.1 (M+1)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08569503B2
Source dataset	uspto-grants-2013_10
ORD ID	ord-46ffad95c7224138a53691a35306d870
Source note	uspto-grants-2013_10