HCID 136350271, compound → HCID 135761783, compound

HRID 1047461Notes

Reaction equation

HRID 1047461 reaction equation
CN(C)C=[O:4].[NH2:6][C:7]1[NH:8][C:9](=[O:25])[C:10]2[N:11]=[CH:12][N:13]([CH:16]3[CH2:20][CH:19]([OH:21])[CH:18]([CH2:22][OH:23])[C:17]3=[CH2:24])[C:14]=2[N:15]=1>O>[OH2:4].[NH2:6][C:7]1[NH:8][C:9](=[O:25])[C:10]2[N:11]=[CH:12][N:13]([CH:16]3[CH2:20][CH:19]([OH:21])[CH:18]([CH2:22][OH:23])[C:17]3=[CH2:24])[C:14]=2[N:15]=1

Participants

3

Reactant 1

HCID 136350271HCID 136350271, compound

Product 1

HCID 135761783HCID 135761783, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
95 °C

Procedure

The compound of formula (XIV) obtained in Example 1-10 (1.1 g) was mixed with distilled water (16.5 ml) and stirred at 95° C. for 1 hr. The resulting solution was cooled to room temperature to crystallize and stirred at 10° C. for 1 hr. The resulting solid was filtered and dried under a nitrogen atmosphere to obtain the title compound with a purity of 99.8% or more as a white-colored solid (0.9 g, yield: 96.9%).

Workup

  1. temperatureThe resulting solution was cooled to room temperature
  2. customto crystallize
  3. stirringstirred at 10° C. for 1 hr
  4. filtrationThe resulting solid was filtered
  5. customdried under a nitrogen atmosphere

Sources & evidence

ORD record
ord-3da68c12f6b84ba389f90f9601b6eb9a
Source dataset
uspto-grants-2013_10
Patent number
US08569491B2

Reaction notes

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