Tetrabutylammonium Fluoride → HCID 67085451, compound

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Reaction Steps

1 M tetrabutyl ammonium fluoride solution in tetrahydrofuran (1.1 L, 1.10 mol) was added to a solution prepared by dissolving the compound of formula (V) obtained in Example 2-9 (426 g, 0.5487 mol) in anhydrous tetrahydrofuran (4 L) and stirred at room temperature for 13 hrs. After completion of the reaction, distilled water (2.0 L) was added to the resulting mixture and extracted with ethyl acetate (2.0 L) twice. The organic layer thus separated was dried over anhydrous sodium sulfate, filtered, and concentrated. The resulting material was stirred in methanol (4.0 L) to obtain the title compound (212.6 g, yield: 72%).

Provenance & Evidence