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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 104750Generated: October 25, 2026

Dichloromethane → 6-(4-chloro-3-trifluoromethyl-phenoxymethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/104750

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDichloromethaneHCID 6344—
ReactantTriphenylphosphineHCID 11776—
Reactant1,1'-(Azodicarbonyl)dipiperidineHCID 73042—
Reactant4-Chloro-3-(trifluoromethyl)phenolHCID 80520—
ReactantTert-butyl 6-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-2-carboxylateHCID 59132278—
Product6-(4-chloro-3-trifluoromethyl-phenoxymethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl esterHCID 69146288—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (2/10)
ORD IDord-73f827d641144a3a9e1b1249fe8e79fb
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (2/10)