Trifluoroacetic acid → HCID 178521829, compound

Participants

Reaction Steps

TFA (2.212 μL, 0.029 mmol) was added to solution of 2,2-difluoro-N-(3-(5-morpholino-1H-benzo[d]imidazol-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)cyclopropane carboxamide (15 mg, 0.029 mmol) in CH2Cl2 (5 mL). The reaction mixture was stirred overnight at room temperature, and then the solvent was removed in vacuo. Purification by flash column chromatography (5% CH3OH/CH2Cl2) afforded the title compound (10 mg) as a yellow solid. 1H NMR: (400 MHz, CD3OD): δ 8.69 (d, 1H, J=1.2 Hz), 7.71 (d, 1H, J=9.2 Hz), 7.68 (d, 1H, J=8.8 Hz), 7.48 (dd, 1H, J=1.6 and 9.2 Hz), 7.35 (dd, 1H, J=1.6 and 9.6 Hz), 7.19 (m, 1H), 3.88 (m, 4H), 3.26 (m, 4H), 2.82-2.74 (m, 1H), 2.19-2.12 (m, 1H), 1.93-1.87 (m, 1H); ESI-MS: [M+H]+: 439.1.

Provenance & Evidence