Trifluoroacetic acid → HCID 178521830, compound

Participants

Reaction Steps

TFA (0.082 mL, 1.063 mmol) was added to a solution of 4,4-difluoro-N-(3-(5-morpholino-1H-benzo[d]imidazol-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)cyclohexanecarboxamide (6 mg, 10.63 μmol) in CH2Cl2 (5 mL). The reaction mixture was stirred overnight at room temperature, and the solvent was removed in vacuo. Purification by flash column chromatography (5% CH3OH/CH2Cl2) afforded the title compound (4 mg) as a solid. 1H NMR: (400 MHz, CD3OD): δ 8.46 (s, 1H), 7.69 (m, 1H), 7.57 (m 2H), 7.18 (d, 1H, J=1.6 Hz), 7.07 (dd, 1H, J=2.0 and 8.8 Hz), 3.88 (m, 4H), 3.18 (m, 4H), 2.55 (m, 1H), 2.17 (m, 2H), 2.01 (m, 2H), 1.96-1.83 (m, 4H); ESI-MS [M+H]+: 481.28.

Provenance & Evidence