Trifluoroacetic acid → HCID 178429877, compound

Participants

Reaction Steps

TFA (0.215 mL, 2.80 mmol) was added to solution of 2,2-difluoro-N-(3-(5-(2-methylmorpholino)-1H-benzo[d]imidazol-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)cyclopropanecarboxamide (15 mg, 0.028 mmol) in CH2Cl2 (5 mL). The reaction mixture was stirred overnight at room temperature, and then the solvent was removed in vacuo. Purification by flash chromatography (5% CH3OH/CH2Cl2) afforded the title compound (9 mg) as a solid. 1H NMR: (400 MHz, CD3OD): δ 8.44 (d, 1H, J=0.8 Hz), 7.64 (dd, 1H, J=1.6 and 8.8 Hz), 7.58-7.54 (m, 2H), 7.17 (d, 1H, J=1.6 Hz), 7.04 (dd, 1H, J=2.0 and 8.8 Hz), 3.99 (m, 1H), 3.82 (m, 2H), 3.52 (m, 1H), 3.44 (m, 1H), 2.84-2.70 (m, 2H), 2.47 (m, 1H), 2.12 (m, 1H), 1.85 (m, 1H), 1.24 (d, 3H, J=6.0 Hz); ESI-MS [M+H]+: 453.1.

Provenance & Evidence