Trifluoroacetic acid → HCID 178428195, compound

Participants

Reaction Steps

TFA (0.432 mL, 5.61 mmol) was added to solution of 2,2-difluoro-N-(3-(5-(4-methylpiperidin-1-yl)-1H-benzo[d]imidazol-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)cyclopropanecarboxamide (30 mg, 0.056 mmol) in CH2Cl2 (5 mL). The reaction mixture was stirred overnight at room temperature, and then the solvent was removed in vacuo. Purification by flash chromatography (5% CH3OH/CH2Cl2) afforded the title compound (20 mg) as an off-white solid. 1H NMR: (400 MHz, CD3OD): δ 8.48 (d, 1H, J=1.2 Hz), 7.43 (dd, 1H, J=1.2 and 8.8 Hz), 7.55 (m, 2H), 7.20 (d, 1H, J=2.0 Hz), 7.06 (dd, 1H, J=2.0 and 9.2 Hz), 3.59 (m, 2H), 2.73 (m, 3H), 2.13 (m, 1H), 1.89-1.77 (m, 3H), 1.53-1.37 (m, 3H), 1.00 (d, 3H, J=6.0 Hz); ESI-MS [M+H]+: 451.2.

Provenance & Evidence