Trifluoroacetic acid → HCID 136232556, compound

Participants

Reaction Steps

TFA (546 mg, 4.78 mmol) was added to solution of 2,2-difluoro-N-(3-(5-morpholino-1H-benzo[d]imidazol-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-yl)cyclopropan-ecarboxamide (25 mg, 0.048 mmol) in CH2Cl2 (5 mL). The reaction mixture was stirred overnight at room temperature, and then the solvent was removed in vacuo. Purification by flash chromatography (5% CH3OH/CH2Cl2) afforded the title compound (11 mg) as a solid. 1H NMR: (400 MHz, CD3OD): δ 8.28 (d, 1H, J=1.2 Hz), 8.19 (d, 1H, J=8.8 Hz), 7.61 (d, 1H, J=9.2 Hz), 7.33 (dd, 1H, J=1.6 and 8.8 Hz), 7.25 (dd, 1H, J=2.0 and 8.8 Hz), 7.13 (s, 1H), 3.86 (m, 4H), 3.21 (m, 4H), 2.78-2.70 (m, 1H), 2.14 (m, 1H), 1.90-1.84 (m, 1H); ESI-MS [M+H]+: 439.1.

Provenance & Evidence