Water → 2-(2-Cyclobutoxy-3-methyl-benzoylamino)-indan-2-carboxylic acid

Participants

Reaction Steps

The mixture of 2-(2-cyclobutoxy-3-methyl-benzoylamino)-indan-2-carboxylic acid ethyl ester (8) (250 mg, 0.64 mmol) and KOH (600 mg, 10.7 mmol) is dissolved in EtOH (8 mL) and water (1 mL) under a water bath. The water bath is removed when KOH is completely dissolved and the resulting reaction solution is stirred at RT for 8 h. After concentration in vacuo, the residue is dissolved in water (20 mL) and the solution acidified with conc. HCl until pH˜3 to yield a precipitate. The precipitate is filtered to give a pure product (9) as white solid (190 mg, 81%).

Provenance & Evidence