Water → HCID 25160411, compound

Participants

Reaction Steps

The mixture of 2-(2-allyloxy-3,5-dichloro-benzenesulfonylamino)-indan-2-carboxylic acid ethyl ester (33) (143 mg, 0.30 mmol) and KOH (500 mg, 8.9 mmol) is dissolved in EtOH (5 mL) and water (0.5 mL) under a water bath. The water bath is removed when KOH is completely dissolved and the resulting reaction solution is stirred at RT for 8 h. After concentration in vacuo, the residue is dissolved in water (20 mL) and acidified with conc. HCl until pH˜3. After filtration, the solid is purified by HPLC to give a pure product (34) as white solid (91 mg, 69%).

Provenance & Evidence