Water → 2-[(2-Ethoxy-naphthalene-1-carbonyl)-amino]-indan-2-carboxylic acid

Participants

Reaction Steps

The mixture of 2-[(2-ethoxy-naphthalene-1-carbonyl)-amino]-indan-2-carboxylic acid ethyl ester (45) (270 mg, 0.67 mmol) and KOH (600 mg, 10.7 mmol) is dissolved in EtOH (10 mL) and water (1 mL) under a water bath. The water bath is removed when KOH is completely dissolved and the resulting reaction solution is stirred at RT for 8 h. After concentration in vacuo, the residue is dissolved in water (20 mL) and acidified with conc. HCl until pH ˜4. The precipitate is filtered to give a pure product (46) as white solid (170 mg, 68%).

Provenance & Evidence