Water → 2-[(Isoquinoline-4-carbonyl)-amino]-indan-2-carboxylic acid

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Reaction Steps

The mixture of 2-[(isoquinoline-4-carbonyl)-amino]-indan-2-carboxylic acid ethyl ester (51) (200 mg, 0.55 mmol) and KOH (600 mg, 10.7 mmol) is dissolved in EtOH (8 mL) and water (1 mL) under a water bath. The water bath is removed when KOH is completely dissolved and the resulting reaction solution is stirred at RT for 8 h. After concentration in vacuo, the residue is dissolved in water (20 mL) and acidified with conc. HCl until no more white precipitate formed. The precipitate is filtered to give a pure product (52) as white solid (170 mg, 93%).

Provenance & Evidence