Water → HCID 59314326, compound

Participants

Reaction Steps

The mixture of 2-[(quinoxaline-5-carbonyl)-amino]-indan-2-carboxylic acid ethyl ester (56) (480 mg, 1.33 mmol) and KOH (1 g, 18 mmol) is dissolved in EtOH (13 mL) and water (1 mL) under a water bath. The water bath is removed when KOH is completely dissolved and the resulting reaction solution is stirred at RT for 8 h. After concentration in vacuo, the residue is dissolved in water (40 mL) and acidified with conc. HCl dropwise until no more precipitate formed. The precipitate is filtered to give a pure product (54) as a brown solid (444 mg, 100%).

Provenance & Evidence