Water → HCID 59314233, compound

Participants

Reaction Steps

The mixture of 2-[(1H-indole-7-carbonyl)-amino]-indan-2-carboxylic acid ethyl ester (57) (220 mg, 0.63 mmol) and KOH (600 mg, 10.7 mmol) is dissolved in EtOH (8 mL) and water (1 mL) under a water bath. The water bath is removed when KOH is completely dissolved and the resulting reaction solution is stirred at RT for 8 h. After concentration in vacuo, the residue is dissolved in water (20 mL) and acidified with conc. HCl until no more white precipitate formed. The precipitate is filtered to give a pure product (58) as an off white solid (186 mg, 92%).

Provenance & Evidence