Water → HCID 59314138, compound

Participants

Reaction Steps

The mixture of 2-[(1,2,3,4-tetrahydro-quinoline-8-carbonyl)-amino]-indan-2-carboxylic acid ethyl ester (63) (259 mg, 0.71 mmol) and KOH (1 g, 17.9 mmol) is dissolved in EtOH (15 mL) and water (1 mL) under a water bath. The water bath is removed when KOH is completely dissolved and the resulting reaction solution is stirred at RT for 8 h. After concentration in vacuo, the residue is dissolved in water (30 mL) and acidified with conc. HCl dropwise until precipitate falls out of the water. After the filtration, the solid is washed by water and collected. The filtrate is acidified with conc. HCl carefully again to see if more precipitate comes out or not. The combined solid is dried in vacuo to give a pure product (64) as a yellow solid (205 mg, 86%).

Provenance & Evidence