反应详情

The mixture of 1,3-dimethyl-5-[(5,6,7,8-tetrahydro-naphthalene-1-carbonyl)-amino]-5,6-dihydro-4H-cyclopenta[c]thiophene-5-carboxylic acid ethyl ester (74) (942 mg, 2.37 mmol) and KOH (3 g, 23 mmol) is dissolved in EtOH (20 mL) and water (1 mL) under a water bath. The water bath is removed when KOH is completely dissolved and the resulting reaction solution is stirred at RT for 8 h. After concentration in vacuo, the residue is dissolved in water (20 mL) and acidified with conc. HCl until no more precipitate formed. The precipitate is filtered to give a pure product (75) as a pale brown solid (832 mg, 95%).

1. customThe water bath is removed when KOH
2. dissolutionis completely dissolved
3. customthe resulting reaction solution
4. concentrationAfter concentration in vacuo
5. dissolutionthe residue is dissolved in water (20 mL)
6. customformed
7. filtrationThe precipitate is filtered