Water → HCID 59314219, compound

Participants

Reaction Steps

The mixture of (cis)-1,3-dimethyl-2-[(5,6,7,8-tetrahydro-naphthalene-1-carbonyl)-amino]-indan-2-carboxylic acid ethyl ester (76) (62 mg, 1.2 mmol) and KOH (300 mg, 5.4 mmol) is dissolved in EtOH (3 mL) and water (0.3 mL) under a water bath. The water bath is removed when KOH is completely dissolved and the resulting reaction solution is stirred at RT for 8 h. After concentration in vacuo, the residue is dissolved in water (20 mL) and acidified with conc. HCl until pH˜4. The precipitate is filtered to give a pure product (77) as white solid (44 mg, 75%).

Provenance & Evidence