Potassium Hydroxide → HCID 59314201, compound

Participants

Reaction Steps

The mixture of 3-methyl-6-[(5,6,7,8-tetrahydro-naphthalene-1-carbonyl)-amino]-6,7-dihydro-5H-[2]pyrindine-6-carboxylic acid ethyl ester (82) and KOH (1 g, 17.9 mmol) in EtOH (5 mL) and water (0.3 mL) under a water bath. The water bath is removed when KOH is completely dissolved and the resulting reaction solution is stirred at RT for 3 h. After concentration in vacuo, the residue is dissolved in water (20 mL) and acidified with conc. HCl dropwise until no more precipitate came out of the water. After the filtration, the solid is purified by HPLC to give a pure product (83) as colorless oil (20 mg, 22%).

Provenance & Evidence