Water → HCID 25159483, compound

Participants

Reaction Steps

The mixture of 2-[(5,6,7,8-tetrahydro-naphthalene-1-carbonyl)-amino]-5-trifluoromethyl-indan-2-carboxylic acid ethyl ester (84) (437 mg, 1.0 mmol) and KOH (1 g, 18 mmol) is dissolved in EtOH (8 mL) and water (1 mL) under a water bath. The water bath is removed when KOH is completely dissolved and the resulting reaction solution is stirred at RT for 3 h. After concentration in vacuo, the residue is dissolved in water (50 mL) and acidified with conc. HCl until no more white precipitate formed. The precipitate is filtered to give a pure product (85) as white solid (408 mg, 100%).

Provenance & Evidence