Water → HCID 25160543, compound

Participants

Reaction Steps

The mixture of 2-(2-isopropoxy-3-methyl-benzoylamino)-5-trifluoromethyl-indan-2-carboxylic acid ethyl ester (94) (690 mg, 1.5 mmol) and KOH (1.5 g, 18 mmol) is dissolved in EtOH (8 mL) and water (1 mL) under a water bath. The water bath is removed when KOH is completely dissolved. The resulting reaction solution is stirred at RT for 8 h. After concentration in vacuo, the residue is dissolved in water (30 mL) and acidified with conc. HCl until pH˜4. The precipitate is filtered to give a pure product (95) as a pale brown solid (495 mg, 78%).

Provenance & Evidence