Water → 2-(3-Methyl-2-pent-1-ynyl-benzoylamino)-indan-2-carboxylic acid

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Reaction Steps

The mixture of 2-(3-methyl-2-pent-1-ynyl-benzoylamino)-indan-2-carboxylic acid ethyl ester (122) (180 mg, 0.46 mmol) and KOH (1 g, 18 mmol) is dissolved in EtOH (8 mL) and water (1 mL) under a water bath. The water bath is removed when KOH is completely dissolved and the resulting reaction solution is stirred at RT for 8 h. After concentration in vacuo, the residue is dissolved in water (20 mL) and acidified with conc. HCl until pH˜4. After filtration, the solid is purified by HPLC to give a pure product (123) as white solid (114 mg, 69%).

Provenance & Evidence