Water → 2-(2-Cyclopent-1-enyl-3-methyl-benzoylamino)-indan-2-carboxylic acid

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Reaction Steps

The mixture of 2-(2-cyclopent-1-enyl-3-methyl-benzoylamino)-indan-2-carboxylic acid ethyl ester (131) (560 mg, 1.43 mmol) and KOH (1 g, 17.9 mmol) is dissolved in EtOH (8 mL) and water (0.5 mL) under a water bath. The water bath is removed when KOH is completely dissolved and the resulting reaction solution is stirred at RT for 8 h. After concentration in vacuo, the residue is dissolved in water (20 mL) and acidified with conc. HCl until pH˜3. The precipitate is filtered to give a pure product (132) as a pale yellow solid (518 mg, 100%).

Provenance & Evidence