反应详情

To a solution of 2-(2-cyclopent-1-enyl-3-methyl-benzoylamino)-indan-2-carboxylic acid (132) (365 mg, 1.01 mmol) in absolute EtOH (15 mL) is added the catalyst, Pd—C (50% wetted powder, 10% Pd, 192 mg, 9% mmol) under argon. The resulting reaction mixture is moved to the Paar apparatus to run hydrogenation: 50 psi, 50° C., overnight. The catalyst is removed by the filtration through a pre-column (10 g silica gel) and washed by EtOH. The combined EtOH solution is concentrated in vacuo. The residue is purified by HPLC to give a pure product (133) as white solid (184 mg, 50%).

1. customThe resulting reaction mixture
2. custom50 psi, 50° C., overnight
3. customThe catalyst is removed by the filtration through a pre-column (10 g silica gel)
4. washwashed by EtOH
5. concentrationThe combined EtOH solution is concentrated in vacuo
6. customThe residue is purified by HPLC