反应详情

To a solution of 2-[2-((E)-2-cyclopropyl-vinyl)-3-methyl-benzoylamino]-indan-2-carboxylic acid (138) (120 mg, 0.33 mmol) in absolute EtOH (10 mL) is added the catalyst, Pd—C (5 wt. % Pd, 28 mg, 1.3% mmol) under argon. The resulting reaction mixture is moved to the Paar apparatus to run hydrogenation: 50 psi, room temperature, overnight. The catalyst is removed by the filtration through a pre-column (10 g silica gel) and washed by EtOH. The combined solution is concentrated in vacuo. The residue is purified by HPLC to give a pure product (139) as white solid (30 mg, 25%).

1. customThe resulting reaction mixture
2. custom50 psi, room temperature, overnight
3. customThe catalyst is removed by the filtration through a pre-column (10 g silica gel)
4. washwashed by EtOH
5. concentrationThe combined solution is concentrated in vacuo
6. customThe residue is purified by HPLC