Potassium Carbonate → HCID 59314238, compound

Participants

Reaction Steps

To a solution of 2-(2-iodo-3-methyl-benzoylamino)-indan-2-carboxylic acid ethyl ester (491 mg, 1.09 mmol) and 2-cyclohex-1-enyl-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (937 μL, 4.36 mmol) in EtOH (10 mL) and dioxane (10 mL) is added palladium anchored homogeneous catalyst, FibreCatPd(0) (4.84% Pd, 240 mg, 0.11 mmol) and 2M aqueous solution of K2SO4 (2.18 mL, 4.36 mmol). The resulting reaction mixture is covered with argon and run in a microwave reaction: 110° C., 8 h. After concentration in vacuo, the residue is purified by HPLC to give a pure product (140) as white solid (95 mg, 22%).

Provenance & Evidence