HCID 68588915, compound → HCID 59314294, compound

Participants

Reaction Steps

To a solution of 2-[3-methyl-2-(1-propenyl)-benzoylamino]-indan-2-carboxylic acid (143) (220 mg, 0.65 mmol) in absolute EtOH (10 mL) is added the catalyst, Pd—C (5 wt. % Pd, 55 mg, 2.6% mmol) under argon. The resulting reaction mixture is moved to the Paar apparatus to run hydrogenation: 50 psi, room temperature, overnight. The catalyst is removed by the filtration through a pre-column (10 g silica gel) and washed with EtOH. The combined solution is concentrated in vacuo. The residue is purified by HPLC to give a pure product (144) as white solid (128 mg, 58%).

Provenance & Evidence