HCID 68589822, compound → HCID 59314127, compound

Participants

Reaction Steps

5,6-Difluoro-2-[3-methyl-2-(-propenyl)-benzoylamino]-indan-2-carboxylic acid (160) (110 mg, 0.30 mmol) is dissolved in absolute EtOH (15 mL) by heating. The resulting solution is cooled to RT and catalyst, Pd—C (5 wt. % Pd, 64 mg, 3.0% mmol) is added under argon. The resulting reaction mixture is moved to the Paar apparatus to run hydrogenation: 55 psi, 50° C., overnight. The catalyst is removed by filtration through a pre-column (10 g silica gel) and washed with EtOH. The combined EtOH solution is concentrated in vacuo. The residue is purified by HPLC to give a pure product (161) as white solid (80 mg, 71%).

Provenance & Evidence