反应详情

To a solution of 2-[2-(3-methoxy-propenyl)-3-methyl-benzoylamino]-indan-2-carboxylic acid (229) (120 mg, 0.34 mmol) in absolute EtOH (15 mL) is added the catalyst, Pd—C (5 wt. % Pd, 93 mg, 4.4% mmol) under argon. The resulting reaction mixture is moved to the Paar apparatus to run hydrogenation: 55 psi, 50° C., overnight. The catalyst is removed by the filtration through a pre-column (10 g silica gel) and washed with EtOH. The combined organic solution is concentrated in vacuo. The residue is purified by HPLC to give a pure product (222) as white solid (80 mg, 49%).

1. customThe resulting reaction mixture
2. custom55 psi, 50° C., overnight
3. customThe catalyst is removed by the filtration through a pre-column (10 g silica gel)
4. washwashed with EtOH
5. concentrationThe combined organic solution is concentrated in vacuo
6. customThe residue is purified by HPLC