Water → HCID 59314397, compound

Participants

Reaction Steps

The mixture (224) and KOH (500 mg, 8.9 mmol) is dissolved in EtOH (8 mL) and water (1 mL) under a water bath. The water bath is removed when KOH is completely dissolved and the resulting reaction solution is stirred at RT for 4 h. After concentration in vacuo, the residue is dissolved in water (20 mL) and acidified with conc. HCl until no more white precipitate formed. After the filtration, the crude solid is purified by HPLC to give 48 mg brown solid (225).

Provenance & Evidence