Acetic Acid → HCID 59314256, compound

Participants

Reaction Steps

To a solution of (225) (48 mg, 0.1 mmol) in acetic acid (10 mL) is added the catalyst, Pd—C (5 wt. % Pd, 21 mg, 1% mmol) under argon. The resulting reaction mixture is moved to the Paar apparatus to run hydrogenation: 55 psi, 90° C., overnight. The catalyst is removed by filtration through a pre-column (10 g silica gel) and washed with EtOH. The combined organic solution is concentrated in vacuo. The residue is purified by HPLC to give a pure product (226) as white solid (35 mg, 86%).

Provenance & Evidence