Ethanol → HCID 25161046, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of 2-(2,3-dimethyl-benzoylamino)-indan-2-carboxylic acid ethyl ester (235) (290 mg, 0.86 mmol), KOH (50% aqueous solution, 1.92 g, 17.2 mmol), EtOH (10 mL) and water (1 mL) are stirred in a 20 mL vial at 50° C. for 30 min. After concentration in vacuo, the residue is dissolved in water (5 mL) and acidified with conc. HCl until no more white precipitate came out of the water. The filtration gives 2-(2,3-dimethyl-benzoylamino)-indan-2-carboxylic acid (236) as white solid (240 mg, 90%).

Provenance & Evidence