反应详情

2-[(Bicyclo[2.2.1]heptane-2-carbonyl)-amino]-indan-2-carboxylic acid ethyl ester (148 mg, 0.45 mmol) is dissolved in EtOH (8 mL), and solid KOH (600 mg, 10 mmol) and water (0.8 mL) are added. The mixture is stirred at RT for 30 min then concentrated in vacuo. The residue is dissolved in water (10 mL) and acidified with concentrated HCl until no more white solid precipitated. The solid is collected by vacuum filtration to give product (273) as white solid (105 mg, 77%).

1. concentrationthen concentrated in vacuo
2. dissolutionThe residue is dissolved in water (10 mL)
3. customprecipitated
4. filtrationThe solid is collected by vacuum filtration