反应详情

2-[4-Methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid ethyl ester (764 mg, 2.02 mmol) is dissolved in EtOH (25 mL), and solid KOH (2.32 g, 40 mmol) and water (2.5 mL) are added. The mixture is stirred at RT for 30 min then concentrated in vacuo. The residue is dissolved in a mixture of water (40 mL) and EtOAc (20 mL) and the organic layer is separated. The aqueous layer is adjusted to approximately pH 7 with conc. HCl then extracted with EtOAc (2×15 mL). The combined organic layers are concentrated in vacuo to yield product (279) as off-white solid (544 mg, 78%).

1. concentrationthen concentrated in vacuo
2. dissolutionThe residue is dissolved in a mixture of water (40 mL) and EtOAc (20 mL)
3. customthe organic layer is separated
4. extractionthen extracted with EtOAc (2×15 mL)
5. concentrationThe combined organic layers are concentrated in vacuo