反应详情

温度

40 °C

A mixture of 2-cyclobutoxy-5-formyl-3-methyl-benzoic acid methyl ester (676 mg, 2.7 mmol), silica gel (5.15 g) and NaBH4 (103 mg, 2.7 mmol) in hexane (30 mL) is heated at 40° C. overnight. The mixture is cooled to RT and filtered, washing the solids with EtOAc (15 mL) and diethyl ether (15 mL). The filtrate is concentrated in vacuo to give product (283) as viscous yellow oil (566 mg, 84%).

1. temperatureThe mixture is cooled to RT
2. filtrationfiltered
3. washwashing the solids with EtOAc (15 mL) and diethyl ether (15 mL)
4. concentrationThe filtrate is concentrated in vacuo