反应详情

2-Cyclobutoxy-5-hydroxymethyl-3-methyl-benzoic acid methyl ester (410 mg, 1.64 mmol) is dissolved in EtOH (15 mL), and solid KOH (1.90 g, 32.8 mmol) and water (1.5 mL) are added. The mixture is stirred at RT for 1 h then concentrated in vacuo. The residue is dissolved in water (10 mL) and acidified with conc. HCl then extracted with EtOAc (3×10 mL). The combined organic layers are dried over anhydrous MgSO4 and concentrated in vacuo to give product (284) as viscous yellow oil (387 mg, 100%).

1. concentrationthen concentrated in vacuo
2. dissolutionThe residue is dissolved in water (10 mL)
3. extractionthen extracted with EtOAc (3×10 mL)
4. dry with materialThe combined organic layers are dried over anhydrous MgSO4
5. concentrationconcentrated in vacuo