反应详情

2-(2-Cyclobutoxy-5-hydroxymethyl-3-methyl-benzoylamino)-indan-2-carboxylic acid ethyl ester (70 mg, 0.16 mmol) is dissolved in ethanol (1.5 mL), and solid KOH (191 mg, 3.3 mmol) and water (1504) are added. The mixture is stirred at room temperature for 30 min then concentrated in vacuo. The residue is dissolved in water (1.5 mL) and acidified with conc. HCl until no more white solid precipitated. The mixture is extracted with ethyl acetate (2×8 mL) and the combined organic layers are concentrated in vacuo to give product (286) as white solid (60 mg, 95%).

1. concentrationthen concentrated in vacuo
2. dissolutionThe residue is dissolved in water (1.5 mL)
3. customprecipitated
4. extractionThe mixture is extracted with ethyl acetate (2×8 mL)
5. concentrationthe combined organic layers are concentrated in vacuo