Water → HCID 25161050, compound

Participants

Reaction Steps

A solution of the 2-(2-cyclobutyloxy-3-methylbenzoylamino)indan-2-acetic acid ethyl ester (288) (400 mg-1 mmol) in EtOH (15 mL)/water (1 mL) is treated with NaOH pellets (800 mg-20 mmol) and stirred at RT for 24 h. After concentration in vacuo, the residue is dissolved in water (30 mL) and acidified with HCl to pH 2-3. The product is extracted into EtOAc (3×20 mL) and the combined extracts washed with water (2×10 mL) and brine (2×15 mL). The organic layer is dried over MgSO4 and concentrated in vacuo. The residue is triturated with heptane and the pure product isolated by filtration to give white solid (350 mg, 92%).

Provenance & Evidence