Cyclobutanol → HCID 59314411, compound

Participants

Reaction Steps

A solution of 2-[(4-fluoro-1-hydroxynaphthalene-2-carbonyl)amino]indan-2-carboxylic acid ethyl ester (303) (197 mg, 0.5 mmol) and 3,3-dimethyl-1,2,5-thiadiazolidine-5 triphenylphosphine-1,1-dioxide (example 307, 245 mg, 0.6 mmol, 1.2 eq) in DCM (6 mL) is treated with cyclobutanol (44 mg, 0.6 mmol, 1.2 eq) and stirred at RT for 6 days. The crude reaction mixture is purified by flash chromatography (100 g silica gel, 100% DCM) to give colorless oil. (120 mg, 54%)

Provenance & Evidence