反应详情

A solution of 4,5-difluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid (388) (220 mg, 0.57 mmol) in methanol (40 mL) is hydrogenated using 10% palladium/carbon catalyst at 40 bar and 30° C. using the Thales nanotechnology H-Cube for 24 hours. The methanol is concentrated to dryness in vacuo to give the product (389) as white solid powder.

1. customat 40 bar and 30° C.
2. customfor 24 hours
3. concentrationThe methanol is concentrated to dryness in vacuo